The following are examples of the types of statistical assistance that Center investigators have received from the Biostatistics Facility Core:

Drs. Steve Colome (Exposure Assessment), William Hinds (Exposure Service), Rob McConnell, Frank Gilliland, and John Peters (Respiratory), and Duncan Thomas (Study Design): Drs. Gauderman and Berhane have worked closely with members of the above-listed cores to design a sampling strategy to augment air pollution exposure assessment in our Children's Health Study.

Dr. Jonathan Buckley (Childhood Cancer): 1) Provided advice on how to analyze DNA patterns in relation to several cancers, 2) Assisted in approaches for cell growth modeling, 3) Discussed designs and provided power calculations for a study of genes and gene-environment interactions in the etiology of childhood brain cancer.

Dr. John Froines (Exposure Assessment): Analyzed a large database of chemical exposures in the workplace to quantify exposure levels to certain toxic substances by job classification.

Mr. Edward Avol (Respiratory): 1) Computed required sample sizes for a study of air pollution and lung function to be conducted in Wuhan, China, 2) Assisted in the design of a study to augment particle exposure monitoring in the Children's Health Study, 3) Discussed air sampling strategies for a study to be conducted in Barrio Logan, California, 4) Assisted in the preparation of a grant application to study the effects of tobacco exposure on COPD, 5) Discussed study design options for a study of the effect of volcanic emissions on children's' health in Hawaii, 6) Analyzed a database of children who moved away from the Children's Health Study to determine whether their lung function growth rates were altered.

Dr. Wendy Cozen (Adult Cancer): 1) Assisted in the design of a study to assess the effects of tobacco exposure on asthma, 2) Provided advice on the use of regression models to analyze T-cell function in a case-control study of twins with Hodgkin's lymphoma and their healthy co-twins.

Dr. Tom Mack (Adult Cancer): 1) Assisted in the design of separate studies of multiple sclerosis, systemic lupus erythematosus, and geographical analysis of single-gender malignancies, 2) Engaged in numerous discussions on the uses of twins to assess genetic, environmental, and gene-environment interaction effects on cancer and other complex traits, 3) Wrote a statistical analysis section for a grant investigating gene-environment interaction for mammographic density.

Dr. Giske Ursin (Adult Cancer): Provided power calculations in the planning stage of a study to investigate possible BRCA1 x Oral-contraceptive interaction in breast cancer.

Dr. Robert Haile (Adult Cancer): 1) Analyzed BRCA1 and OC use in a sample of pedigrees ascertained for having multiple members with breast cancer, 2) Engaged in numerous discussions on the topic of optimal study designs for detecting genetic and gene-environment interaction effects in the context of family-based studies of cancer, 3) Assisted in the design of studies to investigate BRCA1-environment interactions for breast cancer and CYP17-environment interactions for prostate cancer, the latter in conjunction with Ron Ross.

Dr. Jan van Tornout (Childhood Cancer): Provided advice on study design and preliminary power calculations in the planning phase of a study to investigate candidate genes for Wilm's tumor.

Mr. William Linn (Respiratory): Provided data analysis support for a study of air pollution and hospital admissions in metropolitan Los Angeles.

Dr. Beate Ritz (Respiratory): Provided power calculations for a case-control study of gene-environment interaction in Parkinson's disease.

Dr. Smita Bhatia (Childhood Cancer): Provided advice on the design of a family study of pediatric cancer and described how one would perform segregation analysis in such a study.

Dr. Cathy Carpenter (Adult Cancer): Reviewed an application for a young investigator award, which focused on lung cancer, and provided statistical and study design suggestions.

Dr. Leigh Pearce (Adult Cancer): Suggested Poisson/logistic regression methods for a retrospective cohort study.

Dr. Rob McConnell (Respiratory): Wrote statistical sections of a grant entitled "Allergen reduction in homes of children with asthma", which is currently under review by the U.S. Department of Housing and Urban Development.