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| Biostatistics
Facility Core |
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| Members |
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The Director of the Core is Dr. James Gauderman. Dr. Gauderman is an Associate Professor in the Division of Biostatistics in the USC Department of Preventive Medicine. He currently directs the statistical analysis of the Children’s Health Study (CHS) and also directs the Exposure Assessment and Modeling Core of our Children’s Environmental Health Center. In addition, Dr. Gauderman is actively involved in the development of relevant statistical methodology. An area of particular focus by Dr. Gauderman over the last 5 years has been study designs for studies of gene-environment (GxE) and gene-gene (GxG) interaction. This interest has stemmed from requests by, and collaborations with, other Center members. This methodological work has resulted in several published papers related to sample size estimation and analysis of G?E interaction, as well as the development of the user-friendly computer program QUANTO. In his role as director of the Core, Dr. Gauderman oversees the activities of other Core members, consults with Center investigators on issues of study design and analysis, participates in community outreach activities, teaches graduate students and guides thesis projects, and gives seminars on the statistical analysis of health data. Dr. Gauderman will continue as Director of the Core in the future.
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Dr. Jonathan Buckley is a Professor in the USC Department of Preventive Medicine and is the Co-Director of the Biostatistics Facility Core. He has a long-history of providing statistical support for epidemiological studies, primarily through the development of several statistical software packages. These include EPILOG, for statistical analysis of epidemiological data, EPILOG/POWER, for sample size calculations for case-control and cohort studies, and most recently the GENETRIX program. In addition, Dr. Buckley has previously collaborated with Dr. Gauderman and Mr. Morrison on the development of the Genetic Analysis Package (GAP), a program for managing and analyzing pedigree data, including the analysis of complex traits and gene-environment interaction. Dr. Buckley consults with Center investigators in the area of bioinformatics, specifically providing advice and support on how to process and manage high-volume genetic data including gene-expression, SNP, and proteomics data.
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Dr. Kiros Berhane is an Associate Professor in the Division of Biostatistics in the USC Department of Preventive Medicine. He is a statistician on the Children’s Health Study (CHS) and is director of a research project to develop statistical methods for analysis of CHS data. He has led the analysis of air pollution as it relates to symptom occurrence in asthmatic children and as it relates to daily school absences. His other interests include the development of statistical methods for analyzing nonlinear growth curves, with specific application to the analysis of lung function growth in children. In his role as a member of the Core, Dr. Berhane consults with Center investigators in the design of new studies, guides graduate students in the application of statistics to environmental health problems, and gives seminars on issues of statistical methodology.
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Dr. David Conti is Assistant Professor in the USC Department of Preventive Medicine. He has assisted several Center members in the design and analysis of studies aimed at unraveling complex disease pathways that include environmental factors and candidate genes. He has developed a Bayesian modeling framework to analyze complex pathways and along with Dr. Gauderman, has developed a new method for analyzing multiple SNP’s in a case-control study. He will work closely with Dr. Gauderman to consult with Center members on issues of study design and analysis, with particular attention to those problems that involve the bioinformatics support necessary for analyzing large amounts of genetic data.
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Mr. John Morrison has a master’s degree in Biometry from USC and provides programming and analytic support for the CORE. He has worked closely with Dr. Gauderman to develop the program QUANTO, and assists with sample size and power calculations on a regular basis. In addition, he takes primary responsibility for computer hardware and software support, including maintenance of our multiprocessor Core computer and installation of hardware and software on personal computers. He is also available to Center investigators to troubleshoot any computer problems.
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