11/22/2009
 
Research Cores
 
Respiratory Effects
Cancer
Study Design
and Statistical Methodology
Exposure Assessment
Study Investigator:
John Froines
Co-Investigators:
William Hinds
Victor Liu
 
 
Exposure Assessment Research Core
Beryllium
A new area of research concerns exposure assessment for beryllium in the production of nuclear weapons at nuclear defense industries. A safe level of exposure to beryllium is still unknown. Potential explanations include: (1) the current exposure standard may not be protective enough to prevent sensitization, or (2) past exposure surveillance may have underestimated the actual exposure level because of a lack of understanding of the complexity of beryllium exposures. Task-based exposure assessment provides information not directly available through conventional sampling. It directly links exposure to specific activity associated with contaminant generation and provides in-depth evaluation of the worker's role in a specific task. In-depth task analysis is being used to examine physical, postural, and cognitive demands of various tasks.
Core faculty members are developing an automated cascade impactor for collection of task-based size distribution data of beryllium-containing aerosols. Based on the size distribution, the fraction of beryllium-containing aerosol penetrating a respirator and the inhalation and deposition in different regions of the lungs can be estimated.