|
|
| |
Respiratory
Effects Research Core |
|
Acute Cardiopulmonary
Responses |
| There are two studies in progress involving
cardiopulmonary responses. They are found
below: |
| |
Controlled
Laboratory Evaluation of Acute Cardiopulmonary
Responses to Concentrated Particulates:
Healthy Subjects and Asthmatics |
In this project we
evaluate the potential cardiopulmonary and
inflammatory mechanisms in the responses
of human volunteers to controlled exposure
to PM2.5 in Southern California. An ambient
particle concentrator will be installed,
tested, and characterized in a mobile exposure
laboratory. A safety study will be followed
by controlled exposures of adult asthmatics
and healthy controls to concentrated PM2.5.
Endpoints will be symptoms, lung function,
cardiac electrophysiology, and markers of
inflammation and hemostasis in induced sputum
and blood. |
AND |
Acute
Cardiopulmonary Responses to Concentrated
Ambient Particulate Matter in Human Volunteers
|
The acute toxicologic
responses of adult human volunteers to concentrated
ambient particles will be assessed in this
investigation. Healthy, asthmatic, and COPD
volunteers will be exposed to concentrated
fine, coarse, and ultrafine particulates
in an exposure chamber to evaluate acute
cardiopulmonary and other systemic effects
of exposure. The particle concentrator,
developed by Dr. Sioutas of the Exposure
Assessment Research Core, will enable investigators
to utilize actual ambient combustion and
photochemically derived particles in controlled
laboratory circumstances, at concentrations
several-fold higher than on any given ambient
day. This will provide an exposure scenario
whereby acute cardiopulmonary responses
to particles can be more easily modified,
if they are the appropriate health outcomes
of importance in the human particle exposure
pathway. |
| |
|
|
