• To complete our longitudinal study of 6000 Southern California school children and to analyze the results.
• To improve our estimations of exposure on this cohort by work with the Exposure Assessment Research Core in characterizing and quantifying particulate exposure.
• To improve our estimations of exposure on this cohort by developing a valid GIS-based traffic density quantification, and to explore application of this methodology to other studies.
• To understand the relationships between primary pollutants, secondary pollutants and bioaerosols in producing disease.
• To coordinate the efforts of toxicology and epidemiology in understanding both health effects and mechanisms of injury.
• To identify host characteristics (genetic, nutritional and other) that influence adverse responses and identify subpopulations at risk.
• To mount a systematic (center-wide) effort to explain the apparent increase in asthma morbidity and mortality.
• To work with the Adult Cancer, Exposure Assessment and Study Design and Statistical Methodology Research Cores to organize a research study to assess the range of effects from exposure to ambient diesel exhaust.