SCEHSC - Research Cores - Respiratory Effects

11/22/2009

Research Cores

Respiratory Effects

Cancer

Study Design
and Statistical Methodology

Exposure Assessment

Core Director:
John Peters

Co-Director:
Frank Gilliland

Future Research Initiatives

Children's Health Study	Children's Health Study II	Asthma Intervention Project
Cigarette Smoke	TTURC	Uranium Miners
Acute Cardiopulmonary Responses

Respiratory Effects Research Core

Publication List

Traffic, susceptibility, and childhood asthma. Environ Health Perspect 114(5): 766-72. McConnell, R., K. Berhane, L. Yao, M. Jerrett, F. Lurmann, F. Gilliland, N. Kunzli, J. Gauderman, E. Avol, D. Thomas and J. Peters (2006).

Chronic respiratory health effects in Southern California children. Am J Respir Crit Care Med 1996; 153:A478 (Part 2).
Avol EL, Peters JM, Navidi WC, London SJ, Thomas DJ, Gong H Jr, Linn WS, Lurmann FW.

Follow-up of "lost" subjects in a longitudinal air pollution health study. Am J Respir Crit Care Med (in press).
Avol EL, Tan SM, Gauderman WJ, Vora H, London SJ, Peters JM.

Respiratory symptoms, spirometry, and chronic occupational paraquat exposure. Scandin J Work Env Health 1997; 23:421-427.
Castro N, McConnell R, Anderson K, Pacheco F, Hogsted C.

Reduction of nitrate losses from filter and impactor samplers by means of concentration enrichment. Atmospheric Environ (in press).
Chang MC, Sioutas C, Kim S, Gong H Jr, Linn W.

Detection of Trisomy 7 in nonmalignant bronchial epithelium from lung cancer patients and individuals at risk for lung cancer. Cancer Epidemiol Biomarkers Prev 1996; 5:631-637.
Crowell RE, Gilliland FD, Temes T, Harms HJ, Neft RE, Heaphy E, Auckley DH, Crooks LA, Jordan, SW, Samet JM, Lechner JF, and Belinsky SA.

The role of diesel exhaust particles and their associated polyaromatic hydrocarbons in the induction of allergic airway disease. Allergy 1997; 52(suppl 38):52-56.
Diaz-Sanchez D.

Effect of topical fluticasone propionate on the mucosal allergic response induced by ragweed allergen and diesel exhaust particle challenge. Clin Immunol 1999; 90:313-322.
Diaz-Sanchez D, Tsien A, Fleming J, Saxon A.

Differential regulation of alternative 3' splicing of human epsilon mRNA variants. J Immunol 1995; 155:1930-1941.
Diaz-Sanchez D, Zhang K, Nutman TB, Saxon A.

Nasal challenge with diesel exhaust particles can induce sensitization to a neoallergen in the human mucosa. J Allergy Clin Immunol (in press).
Diaz-Sanchez D, Penichet-Garcia M, Wang M, Jyrala M, Saxon A.

Enhanced nasal cytokine production in humans following in vivo challenge with diesel exhaust particles. J Allergy Clin Immunol 1996; 98:114-123.
Diaz-Sanchez D, Tsien A, Casillas A, Dotson AR, Saxon A.

Combined diesel exhaust particulate and ragweed allergen challenge markedly enhances in vivo nasal ragweed-specific IgE and skews cytokine production to a TH2-type pattern. J Immunol 1997;158:2406-2413.
Diaz-Sanchez D, Tsien A, Fleming J, Saxon A.

Projection of health benefits from ambient ozone reduction related to the use of methyl tertiary butyl ether (MTBE) in the reformulated gasoline program. Risk Anal 1997; 17:693-704.
Erdal S, Gong H Jr, Linn WS, Rykowski R.

An evaluation of the scientific peer-reviewed research and literature on the human health effects of MTBE, its metabolites, combustion products and substitute compounds. Report to the Governor and Legislature of the State of California as sponsored by SB 521. Volume II: Human Health Effects, 1998.
Froines JR, Collins M, Fanning E, McConnell R, Robbins W, Silver K.

Combined nasal challenge with diesel exhaust particles and allergen induces in vivo IgE isotype switching. Am J Respir Cell Mol Biol 1998; 19:507-512.
Fujieda S, Diaz-Sanchez D, Saxon A.

Association between air pollution and lung function growth in Southern California children. Am J Respir Crit Care Med (in press).
Gauderman WJ, McConnell R, Gilliland F, London S, Thomas D, Avol E, Vora H, Berhane K, Rappaport EB, Lurmann F, Margolis HG, Peters JM.

Maternal smoking during pregnancy, environmental tobacco smoke exposure and childhood lung function. Thorax (in press).
Gilliland FD, Berhane K, McConnell R, Gauderman WJ, Vora H, Rappaport EB, Avol E, Peters JM.

Non-ceremonial tobacco use among rural American Indians in New Mexico. Tobacco Control 1998; 7:156-160.
Gilliland FD, Davis SM, Mahler R.

Preventive health care among rural American Indians in New Mexico. Prev Med 1999; February; 28(2):194-202.
Gilliland FD, et al.

Trends in survival of American Indian, Hispanic, and non-Hispanic white cancer patients in New Mexico and Arizona, 1969-1994. Cancer 1998; 82:1769-1783.
Gilliland FD, Hunt WC Key CR.

Risk factor information found in medical records of lung and prostate cancer cases, New Mexico Tumor Registry (United States). Cancer Causes Control 1997; 8(40):598-604.
Gilliland FD, Larson M, Chao A.

Spirometer temperature effects on FEV1 in a longitudinal epidemiologic study. Occ Env Med 1999 October; 56(10):718-720.
Gilliland FD, Linn W, Rappaport E, Avol E, Gong H, Peters J.

A theoretical basis for investigating ambient air pollution and children's respiratory health. Environ Health Perspect 1999 June; 107(suppl 3):403-407.
Gilliland FD, McConnell R, Peters JM, Gong H.

Ethnic differences in cancer incidence: a marker for inherited susceptibility? Env Health Perspect 1997; 105 S4:897-900.
Gilliland FD.

A pilot study of controlled human exposures to concentrated ambient fine particles in metropolitan Los Angeles (#13D3). 18th Annual American Association for Aerosol Research (AAAR), Tacoma, WA, October 11-15, 1999.
Gong H Jr, Linn WS, Terrell S, Terrell, L, Sioutas C, Kim S, Chang M.

Acute effects of ozone exposure on cardiovascular function. Am J Respir Crit Care Med 1997; 155:A732 (Part 2).
Gong H Jr, Wong R, Sarma RJ, Linn WS, Sullivan ED, Shamoo DA, Anderson KR.

Allergens reactive with human IgE as natural rubber latex are present in urban ambient air. Clin Immunol 1999; 90:432.
Gong H Jr, Saxon A, Jyrala M, Clark KW, Anderson KR, Linn WS.

Expert Ease (newsletter) 1997; 4(3):3,6.
Gong H Jr. Asthma, the environment, and medicolegal implications.

Attenuated response to repeated daily ozone exposures in asthmatic subjects. Arch Environ Health 1997; 52:34-41.
Gong H Jr, McManus MS, Linn WS.

Cardiovascular effects of ozone exposure in human volunteers. Am J Respir Crit Care Med 1998; 158:538-546.
Gong H Jr, Wong R, Sarma RJ, Linn WS, Sullivan E, Shamoo DA, Anderson KR, Prasad S.

In Asthma in the Elderly. Barbee RA, Bloom JW (eds). New York: Marcel Dekker, Inc. 1997, pp. 219-258.
Gong H Jr. Coexisting conditions that complicate asthma management in the elderly.

Controlled human exposures to concentrated ambient fine particles in metropolitan Los Angeles: methodology and preliminary health-effect findings. Inhal Toxicol (in press).
Gong H Jr, Sioutas C, Linn WS, Clark KW, Terrell SL, Terrell LL, Anderson KR, Kim S, Chang M-C.

Effect of inhaled salmeterol on sulfur dioxide-induced bronchoconstriction in asthmatic subjects. Chest 1996; 110:1229-1235.
Gong H Jr, Linn WS, Shamoo DA, Anderson KA, Nugent CA, Clark KC, Lin AE.

Less common causes of occupational interstitial lung diseases. Curr Opin Pulm Med 1996; 2:405-411.
Gong H Jr.

National Asthma Education and Prevention Program Working Group Report: Considerations for Diagnosing and Managing Asthma in the Elderly. Division of Lung Diseases, NHLBI, NIH. NIH Publication No. 96-3662, February 1996, pp. 1-52. (Contributor to section on coexisting medical conditions in elderly asthmatics)
Gong H Jr.

Outdoor air pollution disasters: planning for lung health. Fact sheet, California Thoracic Society. Approved March 6, 1998. 7 pages.
Gong H Jr, Morris T.

Ozone's effects on health. RT, The Journal for Respiratory Care Practitioners 1996; 9(5):23-28,102.
Gong H Jr.

Pulmonary disease. In: Medical Guidelines for Air Travel. Alexandria, VA. Air Transport Medicine Committee, Aerospace Medical Association. Aviat Space Environ Med 1996; 67b(suppl):B7-B8.
Gong H Jr.

Relationship between acute ozone responsiveness and chronic loss of lung function in residents of a high-ozone community. Arch Environ Health 1998; 53:313-319.
Gong H Jr, Simmons MS, Linn WS, McDonnell WF, Westerdahl D.

Responses of older men with and without chronic obstructive pulmonary disease to prolonged ozone exposure. Arch Environ Health 1997; 52:18-25.
Gong H Jr, Linn WS, Shamoo DA, Anderson KR.

The contrasting effects of CD8+ cells on the primary, secondary and Nippostrongylus braziliensis.- induced IgE responses. Immunology 1996; 88:252-257.
Holmes BJ, Diaz-Sanchez D, Lawrence R, Bell EB, Maizels RM, Kemeny DM.

Molecular identification of individuals at high risk for lung cancer. Radiat Oncol Invest 1997; 5:103-105.
Lechner JF, Neft RE, Gilliland FD, Crowell RE, Belinsky SA.

Individuals at high risk for lung cancer have airway epithelial cells with chromosome aberrations frequently found in lung tumor cells. In Vivo 1998; 12:23-26.
Lechner JF, Neft RE, Gilliland FD, Crowell RE, Auckley DH, Temes RT, Belinsky ST.

Air pollution and daily cardiopulmonary morbidity in the South Coast (Los Angeles) Air Basin. Am J Respir Crit Care Med 1999; 159:A322 (Part 2)
Linn WS, Szlachcic Y, Gong H Jr, Kinney PL, Berhane KT.

Air pollution and daily hospital admissions in metropolitan Los Angeles. Environ Health Perspect (in press accepted 12/1/99).
Linn WS, Szlachcic Y, Gong H, Kinney PL, Berhane KT.

Air pollution, exercise, nutrition, and health. In Lifestyle Medicine. Rippe JM (ed). Blackwell Science 1999, pp. 1215-1225.
Linn WS, Gong H Jr.

Chamber exposures of children to mixed ozone, sulfur dioxide, and sulfuric acid. Arch Environ Health 1997; 52:179-187.
Linn WS, Gong H Jr, Shamoo DA, Anderson KR, Avol EL.

Day-to-day particulate exposures and health changes in Los Angeles area residents with severe lung disease. J Air Waste Manage Assoc 1999; 49:PM 108-115.
Linn WS, Gong H, Clark KW, Anderson KR.

Day-to-day particulate exposures and health changes in Los Angeles area residents with severe COPD. Am J Respir Crit Care Med 1998; 157:A878 (Part 2).
Linn WS, Gong H Jr, Clark KW, Anderson KR.

EPA-regulated pollutants. RT, J Resp Care Practitioners 1997; 10(1):27-30, 94.
Linn WS, Gong H Jr.

Health effects of outdoor air pollution. Compr Ther 1996; 22:673-679.
Linn WS, Gong H Jr.

Lung function in a Southern California outpatient population with chronic spinal cord injury (SCI). Am J Respir Crit Care Med 1999; 159:A314 (Part 2). Also presented at the: American Academy of Orthopedic Surgeons Annual Conference, Anaheim, CA, February 4-8, 1999; American Spinal Injury Association Annual Meeting, Atlanta, GA, April 19-21, 1999.
Linn WS, Adkins RH, Gong H Jr, Waters RL.

Pulmonary function in chronic spinal cord injury: a cross-sectional survey of 222 Southern California adult outpatients. Arch Phys Med Rehab (in press).
Linn WS, Adkins RH, Gong H Jr, Waters RL.

Short-term air pollution exposures and health changes in Los Angeles area residents with severe COPD. Am J Respir Crit Care Med 1997; 155:A425 (Part 2)
Linn WS, Gong H Jr, Clark KW, Anderson KR, Valdez VA, Nugent CA, Shamoo DA.

Short-term air pollution exposures and responses in Los Angeles area schoolchildren. J Expos Anal Environ Epidemiol 1996; 6:449-472.
Linn WS, Shamoo DA, Anderson KR, Avol EL, Hackney JD, Gong H Jr.

Short-term air pollution exposures and responses in Los Angeles area school children. Am J Respir Crit Care Med 1996; 153:A479 (Part 2).
Linn WS, Shamoo DA, Anderson KR, Peng RC, Avol EL, Hackney JD, Gong H Jr.

Short-term particulate exposures and health changes in Los Angeles residents with chronic obstructive pulmonary disease (COPD): a preliminary report of a panel study. In Proceedings of the Second Colloquium on Particulate Pollution and Human Health. Lee J, Phalen RD (eds). University of Utah, Salt Lake City, 1996, pp. 4.271-4.278.
Linn WS, Clark KW, Anderson KR, Gong H Jr.

Standardization of multiple spirometers at widely separated times and places. Am J Respir Crit Care Med 1996; 153:1309-1313.
Linn WS, Solomon JC, Gong H Jr, Avol EL, Navidi WC, Peters JM.

Temperature standardization of multiple spirometers. J Occup Environ Med 1998; 40:148-152.
Linn WS, Solomon JC, Gong H Jr, Avol EL, Peters JM.

The 21st century environment and air quality influences on asthma. Current Opinion in Pulmonary Med 1999; 5:21-26.
Linn WS, Gong H.

Ethnic differences in the prevalence of nonmalignant respiratory disease among uranium miners. Am J Pub Health 1997; 87(5):833-838.
Mapel DW, Coultas DB, James DS, Hunt WC, Stidley CA, Gilliland FD.

Air pollution and bronchitic symptoms in Southern California children with asthma. Environ Health Perspect 1999; 107:757-760.
McConnell R, Berhane K, Gilliland FD, London SJ, Vora H, Avol E, Gauderman WJ, Lurmann F, Thomas DC, Peters JM.

Acute effects of exposure to methyl tert-butyl ether in gasoline. West J Med 1998;169: 375.
McConnell R, Taber R.

Frequency of trisomy-20 in nonmalignant bronchial epithelium from lung cancer patients and cancer-free former uranium miners and smokers. Cancer Epidemiol Biomarkers Prev 1998; 7:1051-1054.
Neft RE, Crowell RE, Gilliland FD, Murphy MM, Lane JL, Harms H, Coons T, Heaphy E, Belinsky SA, Lechner JF.

Concurrent fluorescence in situ hybridization and immunocytochemistry for the detection of chromosome aberrations in exfoliated bronchial epithelial cells. Acta Cytol 1997; 41:1769-1773.
Neft RE, Murphy MM, Tierney LA, Belinsky SA, Anderson M, Saccomanno G, Michels R, Timm S, Gilliland FD, Crowell RE, Lechner JF.

Enhancement of allergic inflammation by the interaction between diesel exhaust particles and the immune system. J Allergy Clin Immunol 1998;102:539-554.
Nel AE, Diaz-Sanchez D, Ng D, Hiura T, Saxon A.

A study of twelve Southern California communities with differing levels and types of air pollution. I. Prevalence of respiratory morbidity. Am J Respir Crit Care Med 1999; 159:760-767.
Peters JM, Avol E, Navidi W, London SJ, Gauderman WJ, Lurmann F, Linn WS, Margolis H, Rappaport E, Gong H Jr, Thomas DC.

A study of twelve Southern California communities with differing levels and types of air pollution. II. Effects on pulmonary function. Am J Respir Crit Care Med 1999; 159:768-775.
Peters JM, Avol E, Gauderman WT, Linn WS, Navidi W, London SJ, et al.

The Allergic Response in Host Defense. In Clinical Immunology. Rich, RR, Fleisher, TA, Schwartz, BD, Shearer, WT, Strober, W. (eds.), 1995, pp. 847-869.
Saxon A, Diaz-Sanchez D, Zhang K.

Alternative RNA Splicing of Epsilon Transcripts Produces mRNAs Encoding Two Membrane and Four Secreted IgE Isoforms. Int Arch All Immunol 1995; 107:45-47.
Saxon A, Max EE, Diaz-Sanchez D, Zhang K.

B cells from a distinct subset of patients with common variable immunodeficiency have increased CD95 (Apo-1/fas), diminished CD38 expression, and undergo enhanced apoptosis. Clin Exp Immunol 1995; 102:17-25.
Saxon A, Keld B, Diaz-Sanchez D, Guo BC, Sidell N.

Effect of spinal cord injury (SCI) level and smoking history on lung function: analysis of an outpatient population from two large rehabilitation centers. American Paraplegia Society Annual Conference, Las Vegas, NV, September, 1999.
Spungen AM, Linn WS, Adkins RH, Gong H Jr, Waters RL.

Enhanced human IgE results from exposure to the aromatic hydrocarbons in diesel exhaust: direct effects on B cell IgE production. J Allergy Clin Immunol 1995; 95:103-115.
Takenaka H, Zhang K, Diaz-Sanchez D, Tsien A, Saxon A.

Double-label suspension immunocytochemistry for detection of gene dysfunction in sputum. J Histotechnology 1997; 20(1):13-17
Tierney LA, Neft RE, Belinsky SA, Lauer FT, Gilliland FD, Crowell RE, Lechner JF.

The organic component of diesel exhaust and phenanthrene, a major polyaromatic hydrocarbon constituent enhance IgE production by IgE-secreting EBV-transformed human B cells. Toxicol and Applied Pharmacol 1997; 142:256-263.
Tsien A, Diaz-Sanchez D, Ma J, Saxon A.

Early IL-4 production driving Th2 differentiation in a human in vivo allergic model is mast cell derived. Clin Immunol 1999; 90:47-54.
Wang M, Saxon A, Diaz-Sanchez D.

IL-4 activates a Stat protein which interacts with a GAS-like sequence upstream of the Ie exon in a human B-cell line: Evidence for the involvement of JAK3 kinase and IL-4-Stat. J Clin Invest 1995; 96:907-914.
Xu F, Saxon A, Nguyen A, Zhang K, Diaz-Sanchez D, Nel A.

Rest and exercise hypoxemia at altitude in non-pure COPD patients is not always predicted by sea level oxygenation or pulse oximetry. Am J Respir Crit Care Med 1997; 155:A910 (Part 2).
Yung RC, Gong H Jr, Farr S.

Germ-line human epsilon heavy chain gene RNA transcripts utilize the full range of alternative 3' splicing seen in productive epsilon mRNAs. Immunology 1995; 85:228-235.
Zhang K, Diaz-Sanchez D, Saxon A.

A comparison of once vs. twice daily dosing of flunisolide (Aerobid) in moderate, well-controlled asthma. Am J Respir Crit Care Med 1996; 153:A343 (Part 2).
ZuWallack R, Rosen J, Cohen L, Rachelefsky G, Gong H Jr, Goldsobel A, Kaliner M, White M, Bronsky E, Chervinsky P, Lotner G, Corren J, Bodenheimer S.

The effectiveness of once-daily dosing of inhaled flunisolide in maintaining asthma control. J Allergy Clin Immunol 1997; 99:278-285.
ZuWallack RL, Rosen JP, Cohen L, Rachelefsky GS, Gong H Jr, Goldsobel AB, Kaliner MA, White MV, Bronsky EA, Chervinsky EA, Lotner GZ, Corren J, Bodenheimer S.