Prior to coming to
USC, Dr. Stram spent two years at the Radiation
Effects Research Foundation (RERF) in Hiroshima
working on the analysis of the atomic bomb
survivor studies, with particular emphasis
on measurement error issues in the chromosome
aberration studies; he remains active in
this area through his own NIOSH grant on
measurement error and as a member of the
NAS Board on Radiation Epidemiology Research.
We have recently published a reanalysis
of the data on lung cancer Colorado plateau
uranium miners, allowing for exposure measurement
error (Stram et al, 1999ab), which showed
that the strong "inverse dose rate"
effect (lower risks for the same total dose
when delivered at high intensity for a short
period) was considerably reduced by this
adjustment. We have also described the application
of similar methods to the studies of cancer
in Utah residents downwind of the Nevada
Test Site (Thomas, 1999c) and the atomic
bomb survivors (Deltour et al, 1999). Dr.
Thomas was a member of the National Academy
of Sciences Committee on the Biological
Effects of Ionizing Radiation (BEIR V),
primarily responsible for reanalysis of
dose-response relationships in these data
and using them for risk assessment; several
methodological publications have resulted
from this activity. He was also a member
of the President's Advisory Committee on
Human Radiation Experiments. We are currently
collaborating with RERF investigators on
the design of a family study nested within
the life span cohort, aimed at studying
the familiality of radiosensitivity. In
addition to the RERF studies, Drs. Thomas
and Preston-Martin have collaborated on
a number of other radiation studies, many
involving the development and application
of novel statistical methods. |